Its not uncommon, and should work Ok.
Especially if you have hubs you can unlock. Then it would not matter if you had a front locker or not.
If you can't unlock the hubs, and don't have a posi or locker, then just keep the speed down a little and it should be OK.
The spider gears will get a little more wear, but not much.
Just remember that the steering and braking are going to be changed, in some cases drastically.
I run a street tire spare on my 250 with 12:50-33s. Naturally the only times I have ever needed it, the flat was on the rear.
Since I have a clutch-type posi, I had to put the spare on the front, then put the front tire on the rear.
Actually did not look any sillier than a car driving down the road with one of those space saver spares.