I used to have a K5 with with 8" Skyjacker lift and 3" body lift on 39.5 TSL Swampers. used to drive it all over DFW with no problems. 76 K10 short bed with 8 and 3 and drove it all over Colorado Springs when I was in the Army there. 84 K10 long bed with 8 and 3 again on 39" boggers. Did they ride rougher than my car? sure, but you have to know what you have and drive it accordingly. I drove an 88 K5 from Virginia Beach to Fort Worth with a 4" lift and 3" body lift on 35s. long distance and had no problems.
another thing you need to consider is once you lift it and put big tires on it, depending on the gearing it will be dog. I had a 74 K10 with a 6" lift and 36" Swampers with 3.07s in high school and right after. I lived 7 miles out in the country. I would drive to town in high range and once in town put it in low range so I would be able to get out of people's way.
to do a big lift correctly there are lots of variables involved: new gearing, driveshafts, brake lines, steering, it takes longer to slow down big tires which is more brake maintenance, accelerated component wear; and probably more that I can't think of right now.
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