My dad did R&D on a 73 3/4ton 454 chevy in 73. The RV industry was worried that gas would hit $1 a gallon and the RV market would go away.
The goal was to get as much HP and MPG as regular gas. He ended up with pop up pistons, cam, head work. I could not tell you how many times he had that engine out. When he was done, he had 2 30 gallon LPG tanks under the bed and a 70 PU gasoline tank behind the seat. Propane was too hard to find.
The truck did not have quite the HP as gas when pulling 16,000lb trailer so he switched to gas for the hills. I bought the truck in 1986 with 145,000 miles on it. No other engine work had been done.
When I towed my boat, I had to switch to propane to get up the hills because gasoline had turned to crap. The oil always looked new at 4,000 mile changes. Finally had a head gasket start leaking at 210,000 miles. Figured a full rebuild was in order.
After going through everything with a mic and GM specs, I replaced all bearings to stock, ball honed the cylinders, new cam and lifters and new gaskets.
The motor now has 310,000+ miles last time I talked to the owner. He took the LPG off. It went in the trash.
If you can find LPG as a motor fuel it is close to $4 a gallon. With gas at $1.55, I do not see the need.