Well, in the past I posted some long explanations. Try search for "frame boxing" about a year ago...
But to summarize.
The GM frame (and other light trucks with ladder frames) was *designed* to flex from end to end at specific rates. When you lock part of it down, the rest flexes against the stiff part and you get metal fatigue followed by failure beside the rigid area. Sometimes it takes a year or two, but it happens. I saw this repeatedly when I ran a frame machine years ago in an area with lots of small logging companies. They used K20/K30s and such with modified (cut down or extended depending) frames. Many times these were done by a "friend that can weld". Almost invariably they scabbed on big "reinforcement plates" or "boxed" the spliced area. 6 months later it looks like a sway back nag and they drag it in to me. Several times I cut out the botched sections and did a backed “but weld” with a non-straight cut to put them back together with grafted in frame sections to replace the junk. Often, with a new customer, I would hear "Why that aint gonna hold, just look how that big heavy piece broke!" /forums/images/graemlins/rolleyes.gif Yeah, right beside the big rigid scab... Then after my repair holds up long after they have broken others, they came back for more of my wimpy work. I never once got one back that broke anywhere near my repair.
If your set on boxing, then you need to do it all to do it right. If your going to box part, then you should definitely fish mouth the plate so that at least it doesn't keep the fatigue too localized. I have never understood why people are so dead set on eliminating the frame flex. The only bad comes when it gets so bad it starts damaging the body or drive train, and there are better fixes for that than making the frame rigid...