I"ve owned several GM trucks with staight sixes--I think my favorite was my '56 Chevy 3100 series 1/2 ton (2wd) that had either a 235 or 261 straight six..very torquey engine!..had only a 3 on the tree,but it was a strong runner,everyone who rode in that truck thought it had a 283 till I opened the hood!..you could lug that motor down to 10 mph in third and just step on the gas,and it would pull right up with no bucking or spark knocking,and the low rumble from the exhaust sounded like a big diesel...
The other straight sixes GM had were great engines--they had 194,215,230,250,and 292's,all of them had excellent reputations for durability and reliability..with a 7 main bearing crank the bottom ends rarely gave trouble..I had a 215 in one truck a friend gave me from his '64 Tempest when he decided to hot-rod it with a 400 Pontiac engine..that little engine might not have been a powerhouse,but it got 16-20 mpg often on long trips in a 2wd 71 C-10...the powerglide tranny made it sluggish though..
I had two of the "Camelhumper" integrated head 250 sixes too,one was in my 81 G-10 van,which I drove to Nashville in '92 when it had "only" 137K on it!..it was a bit slow going thru the Poconos,but it made the trip and back OK,I held that thing wide open the whole trip too,it would top out at about 80-85 mph,and bog down to 53 mph up the hills..but I never feared it failing..I eventually wanted more power ,and swapped in a '73 307 from a Malibu,and it was LESS powerful than the six,it only had 115 HP that year,VS 130 for the 250 six..I wished I had just left it alone!..
My '79 Bonanza C-10 had an integral head 250 too,with only 110K on it when I got it,it ran sweet..but I hated that Rochester 2 BBL "Vari-Jet" carb (Very-JUNK) so much I went thru the agony of making an adapter to bolt on an Edelbrock 500 cfm 4 bbl..it didn't run good with that large a carb,till I discovered I could take the secondary linkage off it and just run it on the primary barrels...unfortunately the engine lost the top ring lands on the #6 piston,probably from the spark knock it always suffered from with the stock carb..I put a 305 in it after it blew,but I missed the six,I would have replaced it with one IF I could FIND one here,but every junkyard I tried said they crushed all the old trucks and they "rarely keep a six,no one wants one"..(I did!)..
A friend used to have a 1982 C-10 that he bought at auction from the local phone company--had a 250 six with the integral head,and a FIVE speed manual!...it got over 20 mpg on trips to Maine he took it on..he eventually replaced that engine with a 250 from an older Nova with a 1 bbl carb,but it soon needed valve work,so he decided to buy a 267 V8 cheap to "upgrade" the truck,along with an automatic tranny,as his left leg had trouble "clutching" after an injury..but he didn't like the truck as much after the six was replaced,and he ended up selling it..
Just this morning on CL I saw a 1977 K-20 listed for 1500 bucks--has a 292 six (the best GM ever made IMO),and an SM465 with 4.10's --ad says its got "plenty of rust" and some holes in the floor,etc,as usual for a truck of that age here--has a working Fisher plow on it too...that would be the type of plow truck I'd like to find,only in better condition body wise...
I would not be scared to take a truck with a straight six on a ong trip--in fact,I'd prefer one over ALL my vehicles in a way--I feel much more confident driving something I KNOW I can fix myself,and do it right on the roadside if need be--hell,with most cars built after 1987,you need a LIFT and multiple tools just to change a belt or hose on one..you face a tow charge and lose the use of your vehicle for a day at the least..I'd rather be in a 60's GM truck with a straight six than say,my '95 Contour,if I had a hose or belt fail on the road!..at least I could FIX the truck!..