Factor in the number of crankshaft rotations per mile
Question is what it is you're trying to optimize. A higher gear ratio number gives you a lower gear, which to me is all torque and no action, a lower top speed and less fuel efficiency, but better getaway from the stop light and towing-trailer-trips up Pike's Peak.
When you factor the tire size into that, you need to consider the leverage that the wheel/tire combination has. The radius of the circle formed by the outer circumference of the tire is like a lever with the fulcrum at the center of the hub. The longer that radius is, the less effort it will take to move it. Think of how big the rear wheels are on an old Ford tractor; or how the sprockets are arranged on the rear wheel of a ten-speed bike - the largest sprocket gives the most torque but least effectiveness at higher speeds (in terms of distance travelled).
So choose the larger tire if you want to get started faster but want a slower top speed, and a smaller tire if you don't need to burn rubber. With the gear ratio you're talking about, you won't have any trouble getting either size tire to get up and go at the stop lights. If you are going to be hauling big weights in huge trailers up the sides of the Rockies, then you definitely ought to get the larger diameter tires and be happy with a top speed of around 45 mph (unless, of course, you intend to buy a new engine every year - the crankshaft has to rotate a lot more to do the same work the higher the differential gear number and the larger the tire diameter).