Narrower wheels will take less grinding. Less BS will take less grinding. I am running 15x8" steelies with 4" of BS. I had to grind a fair amount to get it to clear. Nothing I am worried about safety wise just it took awhile.
Back Spacing can be your friend and your enemy. It will take less grinding to clear the brakes but it will also add extra strain to the ball joints. It will also make your truck wider which may be a positive or a negative depending on your wheeling environment.
If you offroad hard with 2.75" BS rims on a 10 bolt front you will be playing the balljoint game alot. Friends of mine that run that setup can go threw ball joints in as little as 2-3 months depending on the amount of wheeling they get in.
I have run 4" BS with my 10 bolt front for 1 year of hard wheeling and my balljoints are still tight.
If you don't wheel hard or don't mind the balljoint game then 2.75" BS might be ok for you.
Harley