Yes It is possible,but only with some mods or adapter/spacer blocks...they sell a spacer that allows a 2wd truck or car TH350 to replace a 700R4 ,you need a TH350 with the 6" tailshaft housing,which is removed,and some of the output shaft must be cut off in order to get the proper length--the spacer allows the TH350 to be the same length overall as a 700R4 so no other mods are needed to the drive shafts,etc.........some (as in very few) Th400's with short tailshafts from 2wd's or cars will couple to a few T-cases like the Np-208 with no mods,I have heard of some owners having a custom built adapter made to bolt up a TH400 with a output shaft a bit longer than the proper 4x4 version,but that entails driveshafts modifications as far as length,relocating the crossmember,etc....................................................................................................I've seen a few lifted GM's (ridiculously high lifts !) with a 2wd automatic tranny,no transfer case,just to allow it to be used during the summer months ,no more 4x4 capeability...which is probably my last choice!--be better than walking,but would make a truck used for off roading or plowing pretty useless..I wish GM just stuck with divorced transfer cases,then ANY tranny could be swapped in pretty easily...why they have so many different output shaft lengths,spline counts,t-case adapters,and a specific "4x4" tranny,baffles me--you'd think it would have been much cheaper for them to just use the same design tranny in everything,instead of having to tool up to build 20 different ones...