Probably won't need OD alot.
I know it isn't a truck, but my '88 Buick DD has 2.73 gears and a 4T60E (4L60E transverse variant) with a 27% overdrive. It actually gets its best gas mileage around 75-80 mph, no idea what its taching tho. If I drive 40-50 mph steadily, I leave it in drive or it will hunt gears too much.
Some 3.42's or 3.73's would probably be a better idea.