There are a lot of factors involved.....how much throttle, the type of terrain, and some luck. However in my personal experience the combination does not hold up to well. We have a few guys in our club with similiar setups:
1. Ford Bronco on 36" TSL's , stock 400, D44, welded.......broke front stub after first couple of trips, no real rocks just dirt and muddy ruts
2. Chevy Blazer on 37" Boggers, stock TBI 350, D44, locker....I think he broke something everytime out and he never hammered on it.
3. Chevy Blazer on 35" MT/R's (my old setup), stock 6.2, 10-bolt, limited slip....broke two front axleshaft u-joints at different times, no rocks in sight just dirt ruts/ravines and hills