I suspect you can tell 4 vs. 2 by the suffix code, but there are so many different suffix codes it's been (or was) difficult getting much in the way of data to support or disprove that theory.
It should hold true though, since 4 bolts were *typically* used in what GM considered HD applications...Corvette's, HD trucks, etc. Which the suffix code always denoted. Any suffix codes I've got data on (physically verified) that are duplicates, are the same number of main bolts. But there are so many engines that were turned out, it would likely be impossible to say for a fact that XYZ suffix code ALWAYS had 4 bolt mains.