are you talking 2500HD vs 1500? There isn't a direct comparison. My dad gets 10-14, usually the lower end of that, with his 04 6.0L. But that is a 2500HD utility body truck that he drives hard. Bigger trans, axle, and everything = less mileage. 5.3Ls usually get better mileage, but they don't come in 2500HDs, just 1500s. 6.0L 1500s are hard if not impossible to find. They were an option with the Vortec MAXX package, but not sure what year that was first available. I know my buddy had an 03 and couln't get a 6.0L in his 1500. But the 5.3L was great.
What will the truck be used for? I'm guessing DD with light towing here and there? I'd consider a 1500 with a 5.3L. My Dad and I tow at least a few times a week, the 6.0L is nice, Duramax would be nicer.