My M1009 - 6.2 (non turbo)/TH400/NP208/3.08 gears/33in goodyear MTR tires
got 20-23mpg crusing the highway at 55-60mph.
I loved it as a daily driver, and did so for several years, but did enough driving that it justified getting a TDI jetta. No tune ups, no cap and rotor issues, no burned plug wires, no fouled spark plugs, no faulty ignition system, etc. etc. the thing was, and is one of the most reliable engines Ive ever worked with. Even know, wrecked, rusted, and with a failed gas tank, and having sat for 2 years. I can put diesel in a jug, run the line to the filter, and crank that engine and it will fire right up.
The main drawback IMHO is the th400. I hate the shift points for that engine, and lack of overdrive. From what I understand, If you're keeping it relatively stock (nothing more than a 4in lift and 35's), an NV-3500 or NV-3550 is a fantastic upgrade for a physical clutch and an overdrive, with better gear spacing. all three will increase fuel economy over my base 20-23mpg. If a slushbox is your thing, a 700R4 was fairly common behind the 6.2's as well, however I cannot comment on their fuel economy.
The added bonus is that they are also great offroad. unless you're doing dunes and mud bogs where alot of hp is important. I used my truck for camping, and trail rides in GWNF, and never had it get stuck. I just got stopped by some rocks I simply didnt have the gearing to get over (3.08's are great for highway, not so great offroad).