Yes
While I agree with you about the R4 compressor as far as durability and quiet operation, according to what I have read that others have posted on here, the R4 has about 11cfm capacity. The Sanden is less. And you have to make sure that you find a 7 piston Sanden with the 6 bolt rear housing.It may be better for you in the long run to search out a different model compressor.
I am not a big fan of GM's refrigerant pumps.. You can look online or maybe check out some local auto air shops in your area for a conversion kit as swapping to a different model will require a bracket mounting kit as well.
you will have to install a condenser anyway, so step up to the largest condenser you can get in there. Again, aftermarket is probably your best bet especially if you step up the compressor's capacity. You would need to have new hoses made to adapt to the compressor as well, but a good auto AC shop can do these as well...
CCOT systems are pretty forgiving as far as modifications are concerned, and with R-134a you don't have the same capacity as an old R12 system. So it won't hurt to step up to an 8-10 cubic inch pump as long as you increase the condenser as well. Playing with orfice tube size may need to change as well to keep the suction side happy with a larger pump. The old Ford type pump is a great compressor as well as the Sanden and Denso rotary's... since you have V-belts an aftermarket bracket kit shouldn't be hard to find..