If the frame is boxed, it would pick up strength from a piece of tubing passing through and welded to both sides. Yes, there is a lot of leverage from tieing sliders to the frame, but this approach does make things better than just welding tubes to the outside of the C-channel. Even when you look at the bending force that the slider wants to put on the frame, both the boxing and the tube through the middle help. The longer the boxed section is, the more torsional resistance the frame will have.
But as has already been said, the real question is whether or not sliders should tie all the way back to the frame. This would work better on later model trucks where the frame rails are spaced further apart. Now if your tube could pass all the way through BOTH frame rails you would really have something.