Come on guys, this is an easy one, and only Nyyef got it right! Being a Blazer fan means we need to know more than just differentials. Anyway. Bottom line, the difference is the actual PHYSICAL size of the block, displacement has nothing to do with it. There are BIG blocks with stock displacement of 366 ci through 454 ci, and SMALL blocks with 262 ci up to 400 ci. The displacement is deteremined by two MAIN things (connecting rod length and even the thickness of your head gaskets factor in). Bore and stroke. Otherwords the size of the piston and the throw of the connecting rod at which the crank spins it. This is why it is possible, with the right crank and bore to have SMALL blocks with up to 454 ci (that's the biggest displacement I've seen from a FACTORY, not aftermarket block). Two other important differences are weight and price. Big block parts are always almost twice as expensive and a complete big block can weigh up to 800 pounds! That's why it's important to plan ahead when considering a swap. That's not all, you also have to worry about having a strong enough tranny (TH 400), larger radiator, etc., etc. Good luck,