urbex
1/2 ton status
TBI is good stock. Start getting away from stock (in terms of engine modifications like cam, headers, etc) you can start to have issues. Don't need to get into the technicalities, but it cannot adjust fuel accurately outside of a small window where the O2 sensor is used, not when you need more fuel.
Really just about ANY OEM EFI system isn't going to handle much in the way of modifications without tuning, and the TBI systems aren't any different there. However, they can be easily tuned to accommodate changes, but one will still likely run into issues when it comes time for emissions checks if that's needed. I did that for years when I was playing with 1st gen S10s, though the problem today is that they're such old systems that it may be difficult to find someone able and willing to do the tuning, especially considering none of them are flashable. The ECU needs to be opened up, and have the memcal inside changed out.