I don't see any problem it if it will fit the body's interior shape, or one or the other can/will be massaged for it to fit.
Some general advice:
A tube bender is a tool, not an obligation. Design to avoid as many bends as possible. When at all possible put bends in intersections. That avoids discontinuous load paths or openings with more than 3 sides.
Triangles are your friend, and to a point the smaller they are the better. The shame of this is that those triangles can make living with the truck not much fun. Have to strike a balance you can live with.
In ecameron87's drawing of your truck notice what moving the bed area horizontal tube up to the top of the bed does for strength. The lower area does still need some addressing. How much depends on what loads are going to be fed into the cage structure. Could be as simple as continuing the 'V' tubes (even if slightly 'bent') to the lower end of the main hoop and to the lower rear corner.
Might dig up that Total Chaos built Orange/Red Pre-Rnnr I posted a thread with some pics of.