I've ran drive flanges (drive gears) on my front axle for years with a Lock-right after I went 35-spline. Prior to that I had locking hubs. I noticed absolutely no difference on the street when in 2wd between the flanges and unlocked hubs. With no power going to it, the Lock-right or something like a Detroit is unlocked.
Actually, most limited slips would be MORE noticable on the street with drive flanges versus a Lock-right or Detroit. While the lockers are unlocked and basically free-wheel with no power (i.e. t-case in 2wd) while the limited slips are still trying to keep the two front tires turning the same speed.
Generally drive flanges are stronger than locking hubs, and also usually cheaper. The wear and tear is pretty minimal as proven by all of the newer vehicles on the road with no locking hubs. The OEM's figured out the extra cost and complexity of locking hubs did not offset the minimum decrease in wear.