I think the trans has a lot to do with things, too. My rig has a Detroit and a SM465, and you can definately tell the locker is back there. It's not all that bad under normal conditions. It does pop and bang, it does pull you from side to side when going from a coast to drive situation and vice versa. It does squawk the AT's when going around a corner, especially if you really get on it. You know it's there, but with a Detroit, you never have to worry about failure. If it fails, you've got a lot bigger problems than that.
Welded/ Spool? For a trail only rig, no problem. You would lose the torque steer of the locking and unlocking, but they would never unlock. With a locker, you can coast and turn tight without pushing. When you're trying to fit a fullsize into a tight parking spot, you need every bit of help you can get. My truck doesn't like to turn when that Detroit is locked, and pushing the clutch in just leads to popping and bucking, etc., not to mention sudden oversteer.