best way to do it is to get it dynoed at a shop and they'll send the pulls to a company and have a custom chip made or tune it yourself with a wide band and a pocket programmer or prominator.
This may work, but you would also need to have a logger on the truck to map timing vs rpms and map sensor signal. Then you would also need to run the truck at various conditions to see whats happening under part throttle (closed loop) as well. If you do this at a Dyno before you ordered the chip, the motor may not even be close enough to test safely, especially at open loop, plus you would have to pay lot of $ for dyno time, put the new chip in, pay even more $ for dyno time, and repeat, maybe several times... you could easily have $500 into the chip and paying for time at the dyno, if everything goes well. Or you could purchase a wideband o2 setup and a datalogging setup (or download winaldl for free and use your laptop), buy an eprom burning device and the software to use it, or install a flash chip to replace the eprom, get the programming software, and have at it. Either way will cost LOTS of time and money, and pretty much requires a laptop.
OR... just buy a cam that will work with the computers stock programming and use bigger injectors / adjustable fpr and fine tune the fuel pressure, preferrably using a wb o2, but I tuned my 'Burban by feel and reading the plugs, 'cause I'm too poor to buy a wb o2 right now, but I will soon to tune the 383 I'm building...
If youre trying to make over 350 hp or so, you really should just get a Haltech standalone for $800, (they make one thats plug-and-play) and have full laptop programmability, and fuel injector drivers that are strong enough for the application as well. Or, better yet, get a TPI system w/MAF sensor.