These are all things I've either got now, or have been around enough have a solid idea what MPG they tend to get. (Highway numbers)
86 K5 with a 305 and a 2 BBL with 3.42's and 31's would get 16-17 if I was gentle.
95 4wd half ton Dodge truck with a 360 and an auto, 265/75R16's and 3.55's would get 15-16 if I was lucky, and with 35's it would be closer to 13-14.
96 one ton 2wd V10 Dodge truck with 3.55's and 235/80R16's normally would get about 11-12.
94 one ton 2wd Cummins NV4500 Dodge with 3.55's and 235/80R16's would stay around 19-21
4wd GMT800 trucks with 5.3's usually were around 13-15
A late 70's K10 with a high compression 350, an SM465 3.73's and 31's has got anywhere from 7 to 13.
78 4wd Ford F-250, with a 351M, a 4 speed, and 37's and unknown gears saw 8-9 MPG.
78 K20 with a 400 and a TH350 with fulltime 4wd, 265/75R16's and 3.73's usually got around 7-8 MPG.
Tons of 4wd GMT400 trucks with small blocks would see 13-14 with stock size tires, and it would drop to 8-9 with 33's or bigger.
Anything with a big block, 2wd or 4wd, loaded or unloaded, lifted or stock, 31's or 38's, get's 10 MPG.