YES!
I did that in '98. Started a cross country trip in Charlotte NC, with a greasy hub... or so I thought... made it to Shiprock NM, where the 'greasy hub" that was actually my badly oozing wheel bearing decided to let go. Little jerk of the wheel, just enough time to say "what the fu..." and then it was a wrestling match to the death. When the bearing let 80 (at 80mph or so), the wheel fell on the caliper and boiled all the fluid, so I had about half a pump of brakes and then nothing... so I downshifted, and again, and mashed it into 1st finally (surprised me not to bust the rear end but I bet the next owner did!).
When I got it to the shop, the hub had welded itself together, looked like a hunk of blobby aluminum with some springs sticking out of it. The dial was missing, spindle chewed to hell, caliper gone, rim ganked. I ended up needing everything from the knuckle out, including a stub shaft, because the splines were so jacked up. I also needed some tranny work, because using gears as a brake apparently sucks for the teeth, as I chipped a few.
and new underwear, because that was no fun at ALL. hahahah Guys probably still using that hub as a paperweight.