Well it depends one which series of computer cams and generation of engines you are talking about. The way I read what he said, it makes me think of the newer engines that have something similar to VTEC, cant remember exactly what GM calls it, I think its only in the LS2 and newer engines. Believe its called cam phasing or some such nonsense.
The Lt1's, lt5's, ls1's and vortec's (as far as I know) dont have this and the computer controls on them rely on a 'mild' enough grind to allow the computer to not receive contradicting vacuum, speed, knock, etc readings which would confuse it. Basically it boils down to that you could run a 'efi/computer' grind with a carb and it would be just fine. If you tried to run it the other way you may or may not be able to tune it to run properly. Actually, IIRC the cam that is in my truck now has a 112 LSA and can be run with EFI.