You're mistaken if you think sequential fire is that big of a difference over batch or TBI.
Newer setups ARE more efficient, but that is because of the entire engine design, not batch vs sequential.
Batch vs sequential on a 350, same motor, is about 5HP difference. That isn't going to net you much better mileage. Redesigning stroke, bore, chamber design, intakes, and overall block construction, will. (ie, LS series motors)
Sequential is not a good enough reason to forego TBI or batch fire injection. "Wet" intake is TBI's problem, but that is non-existent in port injection setups.
Newer setups ARE more efficient, but that is because of the entire engine design, not batch vs sequential.
Batch vs sequential on a 350, same motor, is about 5HP difference. That isn't going to net you much better mileage. Redesigning stroke, bore, chamber design, intakes, and overall block construction, will. (ie, LS series motors)
Sequential is not a good enough reason to forego TBI or batch fire injection. "Wet" intake is TBI's problem, but that is non-existent in port injection setups.

Excited to hear how yours turns out.