Ton of work to go with an OD trans unless you are doing a lot of freeway driving. Would like to do the 3500 just as a project, but it's nearly impossible to justify in my case, it would never pay for itself even if mileage was fairly improved. The 3500 has been used in fairly stout factory applications, and some have really abused them and had them live, but it's no guarantee.
I Like the idea of OD, but the 4500 comes with generally the same horrid gear splits as the SM465, and the 3500 is better in that regard, which would make shifting more enjoyable, with more usable gears. The only place the 3500 really fails I think, is its input rating, vs the 465 or 4500.