I dunno...
I drive my trail rig on the highway all the time to get to trails, doesn't ever handle uncomfortably. It's got 52s/64s...
Now I'm not trying to say here that they are better or equal on the street to say, some 4" lift 46"s...They allow more brake dive and digging in corners than the super stiff lift springs did for sure. And a stock length lift spring would absolutely be the right choice for a lot of people. Plus, if you moved the frame eye forward to get a proper shackle angle, I'm sure they would have plenty of travel.
What I really want to say is that the 52"s up front (for me) are never as big of an issue as say, the welded rear or the 40s (didn't mind them when I was on 35"s for that matter). I do absolutely have to drive more consciously and carefully than I do in my stock '96 pickup...or my girlfriends Grand Am, but again, that's more due to the fact that my sidewalls are 8" wider than my fenders, they're bias ply, my floorboards are higher than the roof of most cars, etc.
It really depends on the driver. I personally would be fine running 52"s on a DD if I ran some good, stiff shocks. I tend to drive like an old man regardless of what I'm driving, and I'm used to driving in Alaska so I tend to brake early and lightly, coast through corners, etc.
There are not many people I would be comfortable with driving my k5 on busy roads, but I personally do not feel uncomfortable with it. This is the only leaf suspension I would run on one of these rigs if I were going to wheel it at all.
And if you're rock crawling, I'm sure you will be running crossover (someone brought up 52"s needing it). If you aren't planning on it, I highly suggest you reconsider, as braking knuckles or frames on the trail is super not fun. Drag links do not make good limit straps

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More on topic:
I'm about 3-4" over stock with my fenders cut out. I've got 40s and don't have any clearance issues that won't be solved by the bumpstops I'm making. Right now, the springs are soft enough that the go to negative arch slightly at full stuff, which isn't good for the spring anyways, so I'm really not losing anything with bumpstops. I don't think 6" is necessary for anything under a 42". If its a serious rock rig, narrowing the front will solve a lot of clearance issues, and I'm sure you know how poor the peripheral vision is when you're on a technical trail.