I've ran a few on chevy small blocks--Ford's used them in the 60's and 70's,and a version is still sold by Holley today that is a popular swap for the crap Carter 2 bbl carbs on 4.0 Jeep straight sixes..
They come in 350 and 500 CFM ratings (approx)...so they are equal to or more than adequate for a V8 ,the Rochester 2 bbl's GM used were roughly the same CFM ratings..and they even used some on 455's ,so no worries about being too lean..
The ones I used were on a '72 350 engine,I used a carb adapter that Mr.Gasket makes that allows "any 2 bbl carb to bolt to any 2 bbl manifold"...it was a bit of a chore finding the right gaskets to block off all potential vacuum leaks,but once I got past that,and added a hand choke,I liked the Motorcraft carb better than the Rochester...the accelerator pump diaphram can be replaced easily from outside by removing 4 screws,and the gas mileage seemed a tad better too...I never off roaded my trucks to any extreme,so I cant say if they are as flood resistant as they have been claimed to be or not..
Also forgot to add that these carbs were popular on dirt track cars,the rules forbid 4 bbl carbs,so they made an adapter plate to mount the 2 bbl over the existing manifold's 4 bbl openings,some of which can be "slid back" on slotted holes to improve air-fuel mixing...Jegs still sells those adapters..