nah, having a V6 memcal would cause some major timing issues though. A 5.0 memcal will run, but the EST stuff is different. How adverse the effect is, I don't know, but many guys seem to run 5.0 chips on their 5.7s.
Regardless of what memcal is in there, it should still be producing a data stream...
Does the ECM give you any codes? I once got an ECM that would turn the SES light on when you turned the ignition to on, and run the fuel pump for 2 seconds, but nothing beyond that. I discovered it was the ECM by putting a paper clip between the diagnostics in (E12) wire, and ground, which caused absolutely nothing to happen to the ECM. It should always flash code 12 to say everything is good to go.