Can you engineer a one link to have the right anti squat or roll axis angle?
Sure, but it will always have disadvantages compared to a 4 link. A one link suspension is closer to a radius arm setup than it is to a 4 link.
BTW there really aren't any "right" numbers for anti-squat, there's lots of debate about that. Most shoot for 80-100%

Having said that, I would prefer to go triangulated 4-link myself if I ever win the lottery and switch to coilovers. Another problem with a "one-link" is that you have very little control over pinion angle. I don't think you could ever run one in the front, cause your caster would change too much.

time for a beer I think