Alright well In my defense I've never done one of these swaps before so I'm not sure what would be "removed" from the vehicle that would force you to retune the PCM to make it work. My experience includes retrofitting an LS1 24x PCM onto a gen 2 LT1 v8 (originally 4x) and in that case everything seemed to translate over just fine. To your point, I've driven tuned DBW vehicles and the lag can be essentially non-existent in those. If youre factoring in the price of a tune already, i see no issue with DBW. My point was I believe you could skip the cost tune on a DBC engine because (as I understand it) you can use the entire engine/harness/pcm as plug and play.
In regards to reactive/vs predictive I don't think that matters for anything but emissions quality. With a cable throttle, you have absolute control over the manifold vacuum... yes the PCM has to reactively adjust fueling and timing. However both systems still have a TPS to derive data. In DBW its just going to wait to open the throttle until it makes those same adjustments such that mixtures and timing are optimal. In either case, there's a fraction of a second before you get the desired result, assuming the factory tune isn't adding additional engineered lag. If a DBW system is able to optimize those conditions faster, I would attribute that to a newer higher resolution crank sensor rather than the throttle body or reactive/predictive design. I have a mildly hopped up gen 2 LT1 with an ancient 4x resolution EFI and the throttle response is brutal. Anything faster than what that old system is capable of doing isn't going to be noticeable to the average person, but the technology has progressed anyway due to the old reactive systems spitting emissions in the split second moments that timing/fuel doesn't match throttle. A custom tune on either engine should perform the same. Again im arguing from the standpoint of swap simplicity, not that DBW is a bad technology.
The problems with VVT i cited happened on unmodified factory trucks. I have no direct experience with it, but I know one person directly who had to replace an engine prematurely in a 09(?) silverado because of the VVT, and another friend who spent time and money to eliminate the system before it could fail.