finally someone asks a question i know something about!
we'll start with lobe sep:
wider lobe separation will make MUCH more vacuum, also they idle and run smoother and make a fair amount of low-end.
personally:
i've run 750+ hp big-blocks on power brakes, the biggest tip i can offer is use a vacuum canister, the larger the better. as for a specific number, i want to say 10 in/hg and below sucks with power brakes (i could be waaay off on the units, but i'm pretty sure 10 was the lowest i went)
ALSO- amount of vacuum depends on adjustability of the carb, size of the motor, lobe separation/duration of cam and spark timing.
please give me the carb model, cubic inch, cam size etc. maybe i can offer some pointers.
big all-out drag motors (i.e. 550+ CI) make TONS of vacuum.
do you ever tune idle mixture with a vacuum gauge hooked into the manifold? that's a great way to do it and you know how much vac you have.