I have MANY friends that have done this with 283s, 350s, 355s, 383s, and 400s. A few of them drive the trucks every day, including the one with the 283. That kid drive it EVERY day to work, and it cost him a grand total of $85 to build it, including the S10.
The 4.3 L V6 shares bellhousing patterns with the V8s and I think motor mounts too. The 2.8/2.5 share NEITHER bellhousing nor motor mounts but their are bolt ups for the motor mounts now. If it's got a stick shift you can get a bellhousing for the T5 tranny out of a Camaro that will bolt on the 2.5/2.8L tranny and it'll bolt up.
Radiators are easy. Get one out of a 3rd Gen Camaro. you might want the electric fan for it too. It's reversable so you can put it behind the grille. One of my friends has one from a Chevy truck, but the Camaro one is nice, big enough for a V8, cheap at the junkyard, and already aluminum.
If it's 4wd you're going to need a $250 oil pan that comes from either Jeg's or Summit and some other places too.
The rearend is a 7.5" 10 bolt, also found in 3rd Gen Camaros, and has been known to hold up to a reasonable amount of power.
If you have any questions about this, email, PM, or post them here. I can get the info for you. Right now three of my friends are driving them, and one just took his apart after he destroyed the Ford 9" he had out back and the TH 350 he had in it. That's a long story, but it was far from a stock motor. He was sick of it after having it together for a week so he parted it.
My one friend has one in a '94 S10. It's quite weird to see it in a newer truck, but that's why he has it. Oh, BTW, they bought that truck BRAND NEW and a week later had the 350 in it. Cool huh?
Tim
'84 Chevy K10, lifted, loud, fast, and 3/4 ton axles