As mentioned above the tire size and transmission play a big factor in what gear ratio I would recommend. In general the same gears as you would use in gas trucks for the particular combination is a good starting point, with maybe one step higher. For example if 4.56 for a gas engine, than 4.10 for the diesel.
My '90 K5 with the 6.2 diesel came from the factory with 3.73 gears and the TH700r4 overdrive trans. It had 32" tires when I bought it, and I later upgraded to 33's. These axle gears worked pretty good. Later on I switched to 4.10's and have ran 33's, 35's, 38's, and 39.5's on the same gears. Almost no seat-of-the-pants difference between the 3.73 and 4.10 but it worked great for the 33 and 35's on the highway and trail. After going to 38's the overdrive was pretty useless but I didn't care as it was becoming a mainly off-road toy. I drove it on some highway trips before getting a trailer and it did okay, and was fine in low range on the trails. It was a trailered toy by the time the 39.5's came along but still does okay on the road and 4 low is good enough. Wouldn't mind having lower gears but it's low on the list.