That's not how timing works in these setups. Timing is essentially fixed. Here is an example of a timing map (RPM is left, MAP kPa is top):
Really dumbing it down to say that main map there ("advance vs RPM vs MAP") is all there is, but that's the basis of everything the ECM does in relation to timing...it's all based off of that timing map. Everything is based off of those numbers. At 90kPa and 4800 RPM, the setup above will always be working off 22.85* of timing, same for every "cell" there.
The PROM "thinks" it has 0* of base timing (which is what stock is for most of our stuff that I'm aware of, thus why the core support stickers spec 0*, because that is how the PROM is setup). Therefore, 22.85* is 22.85* in the above map. If you advance the distributor physically, and base timing is now 10*, you end up with 32.85* at 4800RPM and 90kPa. But that is a global change (like increasing fuel pressure) and you've now increased timing 10* across that whole map. Might work ok in some spots, and not at all in others.
You may hit the knock sensor, but you don't want to be bouncing off the knock sensor...the problem starts before the knock sensor starts retarding timing. The fact that you can add some base timing on the stock setups means GM was conservative, but they were conservative for a reason...that leaves a margin of error for things like varying fuel pressure, varying fuel quality, etc.
Again, there is a lot more to it than that, but in general...