Man this is a pretty open ended question. I will go with the fact that "most" of your output comes from the box and not the brand of speaker (this has to be within reason and only used on quality subs)
So now you are talking about desining a box for an unknown sub with an unknown purpose. I have 4 vehicles right now with 4 different boxs in each and I like them all, but they all have thier purpose. My 80 Impulse has a 12 cubic foot enclosure for one 15" with a 286 cubic inch port (that is big enough for me to crawl into and I am 6'1") My honda accord has a 4 cubic foot sealed enclosure for 2 12"; my chevy z71 has a custom single reflex bandpass enclosure in it and my blazer has a set of free air on a baffel board mounting in the side (it is going soon since it is an offroad only vehicle)
Now I like all the enclosures and I use all of them for a specific reason. Sealed enclosures will play a wier range of tones, the do require a bit more power to get the same amount of output as a ported enclosure, and they provide more suspension for the sub then a ported enclosure and this leads to a longer life for your subs. So for the general user a sealed enclosure is much better and for a shadetree box builder a sealed enclosure is the best.
A ported enclosure will provide about 3 more DB at the same power input over a sealed, but you will have more wear and tear on the sub itself and you limit yourself to a narrow band of tone. It takes some knowledge to tune a ported enclosure and you can't just take a sealed enclosure and cut some holes in it. I have spent countless hours on the 12 cubic foot enclosure just tuning the port. To kinda show the effect of a port on a sub I can tell you that by removing only 1 inch from my port length I gained 4 db at 70hz yet when I removed one more inch I lost 6 db. The only way to find this is by using a mic and test tones. You can't do it by ear.
Overall without going into a five page summary of all the enclosures I would suggest a sealed enclosure for most subs. Yet you need to design your enclosure for "YOUR" needs and "YOUR SUBS" needs. I would never suggest a new L7 in a small sealed encosure but I would highly recommend it in a large single reflex bandpass. But the Crossfire C2 shines in a sealed enclosure and sounds blown in a ported, unless you step up to a Crossfire P1 that rocks in a small sealed and a large dual ported enclosure, I could go on and on with brand after brand. So in the end it depends on your preference and listening style and your subs.