I will qualify that at this point I am certainly no programming guru, which is why I suggest doing a lot of research on the forums over at thirdgen.org. It takes a lot of reading to even begin to understand some of this stuff.
Power enrichment I believe is where you start getting into trouble, and that isn't at "WOT".
If the right conditions are met, even with a less than optimal setup you may not have any problems, or, if conditions are just not right, you may have the worst possible result.
I know that some shops have the ability to burn PROM's during the dyno session, (or you can use the dyno sheets to get a PROM from the internet) but that's still not as optimal as running it on the street and getting it perfect, which is only going to happen if you learn to do it yourself.
Dyno testing is in a controlled environment and doesn't allow for variations such as the engine load of pushing a 5500lb brick at 60MPH, or different temperatures, both ambient and underhood.