Then why argue that there is such thing as a computer friendly cam? There isn't, that is a fact. If you HAVE to tune it to get everything out of it, then it's not really friendly with the computer.
"Computer friendly", at best, is misleading.
The ECM can only inject the amount of fuel it is programmed to inject (outside of mechanical limits of course). The "on" time of the injector is how it changes the amount of fuel added to the motor. If the valve stays open longer (or opens earlier, or closes later, whatever) the only way more fuel is added is if more fuel is available. The PROM has to be programmed to get that extra fuel in.
On a batch system you are right, there is more fuel available per cylinder because it's "shared" amongst four cylinders...but if you are pulling more for each cylinder, eventually the engine will pull more fuel than is required to keep from running lean, unless the PROM is programmed to give what the engine needs.
I'm not saying they don't make a difference. But if you are going to need to tune something to get all the benefit out of it, why limit yourself to "computer friendly" grinds? You can feel a lot more power in an engine, and still be lean. I suspect these cams are mild enough and GM was conservative enough that there is perhaps an overlap on how much fuel is injected under heavy throttle, but there is no way to know for sure without hooking it up and looking at the data. If it was a serious issue in all uses, these cams would be gone.
I use my Dad's 454 as an example, because it's a very mild motor...Edelbrock performer intake, mild cam, and headers. Fueling was 20% off (lean) from stock, not only 20% on the VE tables, but had to crank the fuel pressure up as far as the TBI pump would go. That's dangerous if undiscovered. It ran fine, you couldn't feel it or tell it any other way. But towing a trailer over the mountains? Someone who likes the throttle?