The ECM needs reprogrammed. Instead of re-typing, you can read my comments here:
https://ck5.com/forums/threads/5-7-vortec-swap-guide.330752/
IME I was able to run .454" lift on the Vortec springs and just barely clear. I can tell you that in terms of the butt dyno, the aftermarket cam with more lift didn't make noticeably more power than the pretty anemic factory Vortec cam. Even though the aftermarket cam I ran was pretty mild compared to what all is possible, it does feel like low end torque is improved with the Vortec cam.
Here is what it looked like last time I took the truck out. This is part of the datalog of my crate L31. Running on the tune from the previous 350 I had in it, with Vortec heads, in the same truck, same induction, but previous engine had a more aggressive cam. The red is for my own emphasis as I look at the data:
Knock count is 112 (and climbing, that is in the middle of the datalog), and it's pulling up to 5* of timing (not shown in that segment) simply due to knock. Not once did it audibly ping. So I put zero credence into anyone saying you can make major changes like heads, cam, and/or intake and have it "run fine", without showing the datalog(s) to prove it.
That same tune, on the previous engine, had 11 knock counts in 45 minutes of datalogging. The picture above is less than 10 minutes of run time.