It could. Usally just causes general crappy running until the engine warms up.
This is in cold climates though. If your in Southern CA, or the temp is warm (above 40-50 degrees), then these things don't effect you as much no matter which position it's in.
More likly you have a carb problem. Does it ever want to backfire on you? Is the timing set properly. Choke adjusted right? Does it only hesitate when warm, cold?