Gas is gas. It burns. My truck drives. I use regular. There's no difference whatsoever if I run 87 or 92, and if there were, it'd be so minute that the extra mileage wouldn't offset of extra cost of the higher grade. Gas goes in, fumes come out, no matter what you put in the tank.
But, on a sad note, the big Freightliner gets better gas mileage then the GMC - even when loaded down!