I'd just use a sissors jack rod & nut--they are (usually) made of good steel to bear heavy weight loads,and you can get a never used one cheap at a boneyard--some sissors jacks acme rod use nylon nuts though,on import cars jacks,those might offer rust resistance and prevent the thing from rusting and seizing up if you dont use the spare for a long time..
But I would prefer a steel nut and grease the rod good though, to prevent it from rusting..I'd be leery of trusting nylon to hold a spare weighing 50+ lbs..
You do not want a spare mounted under a truck coming down on you at speed,believe me..
A vise would have a cast iron nut for the acme rod which would be brittle and not weld well,I'd not use one for this puropse..for what you'd pay for a Harbor Freight vise ,you could just buy acme thread rod and nuts from an online source cheap..I'd just gut a sissors jack..
I had one of my trucks drop the spare when the under the bed spare tire crossmember thing rotted off and let it crash down going 65 mph...saw sparks for 100 feet,and by the time I got the truck off the road and stopped,the sidewall on the spare blew out,rubbed a hole clean through the sidewall..it was "fun" trying to get the truck off the spare,which wedged itself nicely under the rear of the bed,and had taken most of the weight off the springs..
You'll want to use beefy hardware for this job...
BTW--anyone ever see where they put the spare on a 2003 Caravan ?
It is dead center UNDER the van,covered by a plastic cover--it has a crank handle next to the drivers seat to supposedly lower the spare down via a cable...(Ha!)...too bad when the van has a flat there is about 3" ground clearance,no way your getting under it,or that spare out from under it--hell,you cant even fit the jack under it to lift it!..

...great engineering Mopar !..
I learned this the other day at my friends shop,he had one on the lift,and it took him about a half hour of fooling with the mechanism to get the spare to come off !...the owner said he'll never put another tire in that spot ,EVER,after having to get towed in with only a flat tire...
There is room enough IN the van for a spare,I don't know why they couldn't just hide one in the rear quarter like a Suburban ?..
