The '79 C-10 I had wuth a 250 six got between 14-16 mpg,it had the camel humper integrated head engine with the 2SE Rochester carb ,but I put a 600 Edelbrock on it with a home brewed adapter,and dissconnected the secondary linkage..that got a bit better mileage,about 16 - 18 mpg.....................................................................................................After that engine lost the top ring land on the #6 piston,I put a 305 in it from an '86 G-10 van,the gas mileage was no different,and it accelerated like a dragster compared to the six,though the six seemed to pull hills better................................................................................................All the 292's I knew of that friends had,didn't get much over 14 mpg,they had SM465's and low rear end gears,but any long stroke engine usually isn't a mileage champ--the torque is nice though,and worth the extra cost for gas,IMO....but a 454 will get the same or beat 14mpg if its driven and tuned right too...I've had two of them with 450 Holley Economaster carbs and they would do 15 mph on a trip if you didn't use the secondaries--that was before we had ethanol gas too though............................................................................................I think a 4.3 V6 is probably better for mpg than a straight six is,and they come with EFI ,so thats probably an easier swap in the long run....how a chevy six would do with EFI mileage wise is an interesting subject....GM had some in Brazil I think,there must be a reason why they dropped the straight sixes and went to V6 engines I assume..maybe they didn't pan out emission wise or get the MPG they hoped for...or they just plain lasted too long!..those sixes run forever with any care...