@ZombieK5 I will tell you that if you like Quadrajet carbs, I can understand why you are leaning towards using one and keeping it more simple. I still have a a Q-jet on my big block in my '70 K10. It took some work to get it where it is now. When I went to the roller cam, the carb didn't like it. It worked great before that since it had the throttle shaft bushings replaced years before.
I ended up sending it to Sean Murphy Induction. He did a great job and all I had to do was minor adjustments afterwards. I did lean the primaries 2 steps after I got it back, but that was all I did besides adjusting it a little. I can get up to 12 mpg around town if I drive decent, but it will pull a low 16 second quarter mile time as well. (4800 ft elevation) I don't have too many complaints about it for what I do with the truck.
So my experience is that you could run into a problem with tuning a carb depending on the cam. My problem may have been partially due to the carb being from a small block, but as I said, it was fine until the roller cam.
Just my 2 pesos.