first thing you should probably do is read this website this guy made. he put a vortec into an s-10 blazer and the information is all pretty adaptable to a fullsize blazer. when i did my swap, i read this guy's website front to back a few times. here is the link
http://users.apex2000.net/whardie/index.html
the swap is pretty straight forward.
-pull vortec from donor vehicle and fix.
-replace any old worn parts now while you have the engine out(water pump, steering pump, spark plugs, etc.)
-bolt your transmission to vortec.
-you'll need to add a vss of some sort to your tcase(these guys have a number of options
http://www.jagsthatrun.com/Pages/SpeedSensors_Speedometer.html)
-install vortec and trans into truck.
-install tcase.
-install gas tank from 87-91 fullsize blazer. you will also need sending unit from 87-91 fullsize blazer. you will need to use the fuel pump from the '96 donor vehicle. it will supply the high psi requirements of the vortec fuel rail. i believe minimum is 60psi.
-you will need to run new fuel lines that can handle the higher fuel pressure, i had some custom line made from steel braided hose. you just need to run the feed and the return lines, there is also a vapor return line, but it doesn't see the high pressures that the other 2 lines will, so there is no need to change it.
-from there you just have to get all the oil lines and coolant hoses hooked back up and then you can get the thing wired back up.
i didn't purchase a custom wiring harness, i spliced the vortec wiring harness to a blazer firewall connector. i went and cut a firewall connector out of a junkyard truck. there is only like 5-10 splices to make.