Cats are usually more expensive to repair as well,,Detroits' parts are so widely and readily available, there is usually a shorter down time if there is a major repair to be done.
I have driven trucks with the 425 Cat, Cummins, and the Detroits, while yes the Cat pulled pretty awsome, the fuel mileage just wasn't that great, the Cummins,,,i just did not like all around, but the Detroits i have personally never had a problem. Some say otherwise.
The detroits that were really nice i thought were the split 435/470hp setup,,wide open road, not much drag on the motor, it would run at 435hp, when ya start climbin hills or needed that power, it would kick it up to 470.
Only driven with a few different types of trans, 9spd, straight and super10's,
the full auto 10's, and a 13spd,,,i REALLY liked the 13.