There's another thread going on about building a performance I-6.
My question on that thread was: Why? A 350 small block Chevy can be built to give excellent performance at a very reasonable cost.
Back to this thread. Same question. Why?
The 454 was a factory option in the Suburban and in 3/4, and one ton trucks. That means you have OEM engine mounts, bellhousings, transmissions, exhaust manifolds, engine accessories and brackets, radiators, radiator hoses, fuel lines, wiring harnesses, etc, etc, etc, available in wrecking yards or at your dealer.
Big block Chevy parts are a little more pricey than the small block ones, but they're much less than Caddy parts. There is a ton of information out there on making a big block perform better.
"But the Caddy motors make more torque". I'll raise the BS flag to that.
A 1972 Cadillac 500 makes 235 HP and 385 ft lbs of torque. Well a 1987 454 TBI makes 230 HP and 385 ft lbs of torque. And it makes it's peak torque at 1,600 rpm as opposed to 3,800 rpm for the Caddy.
"But the Caddy is lighter". 50 lbs, BFD.
If a 454 isn't big enough, get a 502.