Yeah, but it would at least be injected.
But yes, the no-distributor issue would be somewhat problematic. With no "E" tranny however, the ignition problem has probably already been worked out.
I know coil on plug setups have been made to work with earlier EFI so if other people have done it, the knowledge is already out there. Doesn't cost anything to research.
Tuning would definitely be required, but I assume any retrofit requires some tuning, if just for gearing differences?