Hey all- Thanks for the replies.
I figure I'd see someone who said I might be dissapointed with a 353

. For starters I plan on using a turbo off a 6V53 twin turbo, and larger injectors. The motor in question is an aluminum block motor that uncle sam spec'd for off road army vehicles, and has 2 oil pumps in the event it was going up a steep grade. That being said, the back of the block is cast off, no plate and gasket like the naturals, so boost isn't "so limited" to a certain pressure as before (why turboing a natural detroit is a bit of a problem). Like I said all this has been done before by others, one I know right off the top of my head is a 353T turbo block with natural pistons and the same turbo and injector setup I plan on using. Needless to say I would be weary of punching the throttle hard- might break something

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As for the throw away motor I planned on using (aka 3208), I know where there is one in an 80s twin screw Topkick, and I beleive it has a 13spd fuller in back of it. Runs great, would be a shame to part it from the truck, both are from texas and in nice shape. Only problem with the 3208 is that I find they are a hyper motor and a pickup driveshaft and axle breaker, and 6?? cubes is a big motor to start with. Lots of front end weight there, while a cast iron 353 weighs a hair more than a big block. Personally, I am looking to build a daily driver, and the 353 that I plan on building up would be best suited. I know of several cats (3208s and larger) put under the hoods of 70s Fords, have considered them as well. Although, the Ford body makes it worth a hell of a lot less. Maybe even a 3304 with a turbo?? Its a good deal smaller. As for the 6.2L I don't mind them terribly, but I plan on building something with a commercial motor. Not a big fan of the B Cummins, I know of a couple 3.4L A's (from Grumman vans.) Even a V6 cummins out of some construction vehicles would be a neat build

. As for the Internationals, they arent terrible in my opinion, although you go to the dealer for parts and the money you spend would make a grown man cry. DT466 is out of the question... fuel mileage sucks, but they do last a good long time.
I guess I have more research to do- If I get really ambitious and loose my sanity some more I might do up a 5.7L Olds

Anyone have some more pictures of the stuff they built? I thought that 6V53 in that 3500 looked cool along with the 353 in that 1/2 ton pickup. Thanks for the replies, and any more feedback or input is appreciated.