How much are you looking to spend? You can gain 60 hp easy with an offroad cam, offroad carb, and a good crosswind manifold. Most likely it will be more than that but that is really all the power you'll ever need.
In 4 lo anything becomes a goat but there is a huge difference between how a four cylinder and a v8 will spin the tires. Tired of people saying a 4 banger will spin 44's....yeah it will but real slow and only in 4 lo.
The only place you need anymore hp than the 350 has stock is going up hills on the highway. My last motor was almost stock had a k&n and 3" exhaust and maybe a chip and it would shift down to third on the highway when i hit a hill. Always hated that cause i had a job at the lake and was spending 5 bucks everyday just going to work. 60 hp or a little more will cure the feeling that your using everything its got but there's ALOT of other mods you can do to a 350 to make well over 500 hp without forced induction.. but you start to feel it in your wallet.
A good offroad carb is real important because roads carbs will stall a lot sooner going up a hill than an offroad carb. If you use ebay you can get a new crosswind manifold for about 140. the crosswind design made 14 more hp than a regular edelbrock eps performer. I would get a good cam, an offroad carb about 650-750cfm, and a crosswind manifold for about $450 total on ebay. You can keep going with dyno tuning, spacers, heads, headers, intake coolers, ignition/distritbutor, fuel pump, higher rev limiter, etc etc etc its all just making a pump breath better.